1. Select Number of CP Sequences
Choose the number of cyclic peptide sequences you want to analyze. Adjust this based on your experimental requirements.
2. Specify Length of CP
Enter the number of amino acids that make up your cyclic peptide. This helps tailor the prediction to your specific
peptide structure.
3. Choose Cyclization Type
Determine how the peptide ring is closed. CycloPermIAbility currently supports:
Head-Tail Cyclization: This common form of cyclization involves linking the N-terminal (head) of the peptide to the
C-terminal (tail), forming a closed ring structure.
Head-Side Cyclization: This form of cyclization involves linking the N-terminal (head) of the peptide to a side chain of
one of the amino acids in the sequence, creating a branched ring structure. For this option, select the branch terminal
amino acid position and the branch position within the cycle.
4. Input CP Sequence
Select the amino acids for your cyclic peptide sequence from a predefined list. This ensures compatibility with the
prediction model. A 2D depiction is displayed after selection to assist with your choices.
5. Run Predictions
Execute the prediction algorithm to receive detailed insights into the membrane permeability of your cyclic peptide.